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A pandemic (from Greek πᾶν pan "all" and δῆμος demos "people") is an epidemic of infectious disease that has spread through  populations across a large region; for instance multiple continents, or even planet wide. A widespread endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic.

24,455 pandemic (planet wide disease) cases have been reported since 2333 within Union Space.

- The famous Dai Fever that often affects entire Clans was not considered a Pandemic as the disease was known before the Dai joined and by the time they did an effective immunization treatment was available.

- The Malakean Pest was the most severe case affecting 400 planets and claiming 13 billion lives in 4901

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